Celtic's losses to Hearts and Kilmarnock have left the door ajar for Rangers, who could narrow the gap at the top of the Scottish Premiership to two points with a win at Parkhead on Saturday.
However, they have won just one of their last eight league meetings against their great rivals.
Over 2.5 goals - 17/20
The Old Firm derby is always one of football’s most hotly contested matches, but Rangers will sense they can make huge inroads in the Scottish Premiership race if they can win at Celtic on Saturday.
The Bhoys have a five-point lead in the title race, but there has been some disquiet at Parkhead lately as the dominance they enjoyed under former manager Ange Postecoglou is not being replicated under Brendan Rodgers.
They have recently suffered defeats to Kilmarnock and Hearts and while successes against Livingston and Dundee have steadied the ship, this is going to be a severe test.
The Gers have been reborn under Philippe Clement since the Belgian took the Ibrox reins from Michael Beale - they head across Glasgow having gone unbeaten in their last 16 matches.
They have won the League Cup and finished top of their Europa League group and key to the equation is that they have two games in hand on their great rivals after their home match with Ross County was called off on Wednesday, which afforded them a couple more days of rest.
So, the emphasis for them will be to be positive, as a win would blow the title race wide open, meaning we could be served an entertaining clash.
The Gers, who will have no fans at Parkhead, have conceded just twice in their last eight league away games, but they face a stronger force here and, with the motivation there for the home side too, regardless of the arch-rivalry, over 2.5 goals looks the way to go.
Luis Palma – to score or assist - 5/4
While there is plenty of disquiet at Parkhead, Rodgers will at least be pleased to see that his team are creating lots of chances.
They had 23 attempts at goal on Tuesday against Dundee and forced 23 corners in that clash and one player who has been at the centre of things is midfielder Luis Palma.
The Honduran has scored seven goals for the Bhoys since joining from Greek side Aris Thessaloniki at the end of the last transfer window and has posted three assists in his last two matches.
The 23-year-old has had at least three efforts on goal in eight of his last 13 appearances and looks a good price to score or have an assist in the biggest match of the Scottish domestic season.
Celtic are waiting on defender Cameron Carter-Vickers, who suffered a tight hamstring in the Boxing Day win at Dundee.
He will undergo a late fitness test, but Odin Thiago Holm is struggling with illness. James McCarthy and Tomoki Iwata are ruled out, while the game could come too early for Liel Abada and Reo Hatate.
Connor Goldson faces a late test on his groin injury and Clement has a full treatment room to contend with.
Jose Cifuentes, Danilo, Tom Lawrence, Nicolas Raskin, Kemar Roofe, John Lundstram, Steven Davis, Borna Barisic and Ryan Jack are all ruled out.
Celtic have lost just one of the last eight league Old Firm derbies.
Rangers have scored in six of their last eight league visits to Parkhead.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.