Newcastle's Champions League ambitions were checked by Borussia Dortmund when they were beaten 1-0 by the Bundesliga giants at home but the in-form Magpies should be confident of getting a positive result from their trip to Germany on Tuesday.
Newcastle are on an upward trajectory - underlined by Saturday's statement 1-0 win over Arsenal in the league - and they will head to the intimidating Signal Iduna Park safe in the knowledge that they can cause the hosts plenty of problems.
The narrow 1-0 defeat in the first game between the sides on matchday three could have gone either way in truth, and the Toon will hope they can edge it away from home to silence the Yellow Wall.
Where is Borussia Dortmund v Newcastle? Signal Iduna Park, Dortmund
When is Borussia Dortmund v Newcastle? 17:45, Tuesday 7th November
Where can I watch Borussia Dortmund v Newcastle? TNT Sports 1
Back in the Champions League for the first time in 20 years, Newcastle have proved they can cope going up against the established European big guns as they have already drawn 0-0 in the San Siro against AC Milan before they then memorably beat Paris Saint-Germain 4-1 at home.
The 1-0 defeat at St James' Park against BVB on matchday three was an unwelcome setback but the Magpies were competitive throughout and arguably had the better chances to win the game.
Therefore, a trip to Dortmund shouldn't hold too many fears and, with confidence in the camp high after an eye-catching 1-0 home win over Arsenal in the Premier League on Saturday, Newcastle can come out on top.
They have matchwinners all over the pitch, including an in-form Anthony Gordon, forward Callum Wilson and the energetic and creative Miguel Almiron.
It's also worth bearing in mind that Dortmund come into the clash on the back of a chastening 4-0 home hammering at the hands of rivals Bayern Munich in Der Klassiker on Saturday - a result which may take some getting over for Edin Terzic's men.
If Newcastle are to edge what is set to be a tight game, then key striker Wilson could be the difference.
With Alexander Isak currently out injured, Wilson is Eddie Howe's main goalscoring hope and the striker looks a good option at 7/4 to find the back of the net in Dortmund.
The 31-year-old has scored seven league goals already this season and should open his Champions League account sooner rather than later. He has attempted 22 shots this term all told, of which 13 have been on target and, if he gets a chance in Germany, he will expect to take it.
In the first game between the sides, despite not scoring, Wilson was involved in a lot of his side's good attacking play and he had two shots across the 90 minutes, one of which was on target.
Wilson is also on penalty duty for the Magpies and that is another important consideration when looking at the goalscorer market for the visitors against Dortmund.
Emre Can is struggling with a hip problem and is a major doubt for the hosts, while Mateu Morey and Julien Duranville are set to be absent due to knee injuries.
Dan Burn suffered a back injury against Arsenal and looks set to miss out, while Jacob Murphy injured his shoulder again against the Gunners and adds to Howe's injury woes.
Elliot Anderson and Harvey Barnes are both out longer-term, while Isak and Sven Botman also remain on the sidelines for the Toon.
Last month's 1-0 win for Dortmund at St James' Park was the first competitive meeting between the two sides.
Dortmund are fourth in the Bundesliga, seven points behind leaders Bayer Leverkusen, and Saturday's big home defeat to Bayern Munich was their first loss in the league this season.
Newcastle are up to sixth in the Premier League after beating Arsenal at the weekend.
Howe's side have only lost one of their last 12 games in all competitions - but that was the 1-0 home reverse in the Champions League against Tuesday's opponents.