Argentinian giants Boca Juniors sit third in Copa Libertadores Group D after five games so they need a result against group leaders Universidad Catolica to secure a spot in the knockout stages.
Visitors Universidad Catolica have lost just one of their five matches and know that a draw in Buenos Aires during the early hours of Friday morning would be enough to take top spot.
However, they lost the reverse fixture against Xeneize, and they head into this decider as firm underdogs.
Best Bet - Universidad Catolica win or draw double chance @ 7/4
Alternative Bet - Under 2.5 goals @ 8/11
Bet Builder - Fernando Zampedri to score, Justo Giani 2+ shots & Miguel Merentiel 2+ shots on target @ 10/1
Best Bet: Universidad Catolica win or draw double chance @ 7/4
After a disappointing elimination from the Argentina Liga Profesional play-offs at the hands of Huracan, Boca failed to capitalise on their dominance over Cruzeiro on matchday five of the Copa Libertadores group stage and sit third in the standings as a result.
Only a win will guarantee them a position in the knockout stages, but they may fall short against group-leading Universidad.
Boca scraped a fortunate win in the reverse fixture in April, but they head into this decider with just one win from their last four games and winless in their last three in this competition.
Los Cruzados have lost just one of their last seven games and know that a draw would secure top spot in Group D. They have won both away games in this competition and look good value to get the result they need in Buenos Aires.
Alternative Bet: Under 2.5 goals @ 8/11
Boca and Universidad have conceded only eight Copa Libertadores goals between them and, with both sides' futures in this competition on the line, another tight affair is expected.
Each of Boca's last three games on the continent have featured fewer than three goals, while Universidad's last two in this competition have produced just two goals in total.
There may have been three goals scored in the reverse fixture in Chile, but they came from only 1.77 expected goals and seven shots on target, so a low-scoring game could be on the cards.
Fernando Zampedri to score
Justo Giani 2+ shots
Miguel Merentiel 2+ shots on target
Pays 10/1
Fernando Zampedri has scored 16 goals in 17 starts for Universidad Catolica this season and the 38-year-old could make all the difference in Argentina.
He netted two goals in his last Copa Libertadores game and has scored four goals in his last four starts, registering 11 shots and seven on target over that same period.
Team-mate Justo Giani has not found the same success in front of goal recently, but that is not for a lack of trying.
Giani has attempted a massive 64 shots in 18 games this season and has had at least two attempts on goal in 17 of those matches, including each of his last 12 outings.
He had two shots and one on target against Boca Juniors and looks set to be an attacking threat once again.
Boca Juniors forward Miguel Merentiel found the net against Cruzeiro last time out, continuing his shot-taking streak in the process.
He has had 12 shots in his last four appearances and has hit the target with 10 of those.
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Boca Juniors are winless in their last three Copa Libertadores games
Universidad Catolica are unbeaten in four matches in the competition
Just two goals have been scored in Universidad Catolica's last two Copa Libertadores games
Under 2.5 goals has landed in Boca Juniors' last four fixtures
Fernando Zampedri has scored 16 goals in 17 starts for Universidad Catolica
Justo Giani has had two or more shots in 17 of his 18 appearances this season
Miguel Merentiel has had 10 shots on target in his last four appearances
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.