Both Barcelona Women and Manchester City Women have qualified for the next stage of the UEFA Women's Champions League but top spot is still undecided in Group D.
City won the pair's opening fixture 2-0 at the Manchester City Academy Stadium in October and sit on 15 points, three clear of Barca, with both sides having won their other home and away fixtures against Hammarby and St Polten.
Gareth Taylor's visitors lost their last game 2-1 at Everton and take on a team who have not lost a 'home' fixture since going down to Chelsea in the first leg of last season's semi-finals, only to roar back and win before beating Lyon in the final to secure their third title.
There is a caveat, with the Estadi Olimpic Lluis Company not the Blaugranes' usual ground. However, having claimed this title in three of the last four seasons, losing the final in the other, they are unlikely to be intimidated by their change of scene.
Barcelona Women to win and over 3.5 goals - 13/10
Barcelona are just 2/11 in the match betting and it is easy to see why considering their home record and recent European success.
They have collected a perfect 13 wins from as many games in the Primera Division Feminina and their loss in Manchester is their sole setback this season.
Pere Romeu's side warmed up for this game by winning 1-0 against Valencia but have been more clinical at home, scoring 49 times in their eight outings in the Catalan capital.
However, they conceded in five of those and the visitors could grab a goal, albeit in defeat. That would see Group D come down to goal difference in the games between the two sides and there looks to be real value in the home win and over 3.5 goals in the game.
Ewa Pajor to score two or more - 9/2
Polish striker Ewa Pajor has contributed 10 of her team's home goals and was also on target in their last UEFA Women's Champions League game, a 3-0 win at Hammarby.
The 28-year-old joined Barca in the summer from Wolfsburg and has more motivation than most to win this tournament, having been a four-time runner-up during her spell in Germany.
Switching to Spain has allowed her to reunite with fellow former Wolfsburg forward Caroline Graham Hansen and the duo are bringing the best out of each other.
Pajor looks to have settled well into the new chapter of her career and can further endear herself to the locals by grabbing a brace or more on Wednesday.
Mary Fowler anytime goalscorer - 13/2
Khadija Shaw's absence means City have had to share the goals around and Mary Fowler is among those who have stepped up.
The 21-year-old scored a consolation from the penalty spot against Everton and was also on target in the recent 4-0 win over Leicester.
Shaw's duel with former Manchester United defender Ona Batlle could be sensational and she is well priced to add to her five for the season in all competitions.
Read more football betting tips and predictions on site
Barcelona Women - 2/11
Draw - 6/1
Manchester City Women - 17/2
View the full market and more odds for Barcelona Women v Manchester City Women on site
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.