Hansi Flick takes charge of his first competitive home game though not at the Nou Camp, with Barcelona playing at the nearby Montjuic for the first few weeks of the season.
Barca needed a Robert Lewandowski double either side of half-time to come from behind to win 2-1 at Valencia in their season opener.
Athletic Bilbao took the lead at home to Getafe but were pegged back in a 1-1 draw at San Mames.
Barcelona v Athletic Bilbao is available to watch on bet365's Sports Live Streaming Service and also Premier Sports 1.
Barcelona v Athletic Bilbao will kick off at 18:00 BST on Saturday 24th August at the Montjuic Stadium, Barcelona.
Barcelona have not lost to Athletic in any of their last nine La Liga meetings, winning seven and drawing the other two.
Athletic haven't even found the net in any of those last five showdowns, most recently a 0-0 draw in Bilbao in March.
The Basque side did, however, knock Barca out of the Copa del Rey last season, winning 4-2 after extra-time in a quarter-final tie and going on to lift the trophy.
Barcelona wins | 121 |
Draws | 40 |
Athletic Bilbao wins | 80 |
* H2H stats refer to all competitions
Read the latest tips, predictions and odds for Barcelona v Athletic Bilbao.
With Ronald Araujo injured, Andreas Christensen could come back in for Pau Cubarso at the back of Flick's 4-2-3-1 set-up.
Pedri could muscle his way into the three in support of Robert Lewandowski though Dani Olmo, their new recruit from Leipzig, has yet to be registered even though Ilkay Gundogan's return to Manchester City has freed up a space.
Veteran right-back Oscar de Marcos is fit to challenge Andoni Gorosabel for a start.
Nico Williams, who came off the bench against Getafe, is expected to start against the club who have spent the summer trying to sign him.