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Fantasy Gameweek 21 Picks: Differentials, ones to watch, captain & more

The conclusion of the third round fixtures in the FA Cup means the return of the Premier League for Gameweek 21, headlined by Nottingham Forest's top of the table clash with Liverpool.

Here is everything you need to know ahead of Gameweek 21 of bet365's Premier League fantasy football game.

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EPL Fantasy Season Game

Fantasy Gameweek 21 fixtures

Tuesday 14th January 2025

  • 19:30 GMT: Chelsea v Bournemouth
  • 19:30 GMT: West Ham v Fulham
  • 19:30 GMT: Brentford v Manchester City
  • 20:00 GMT: Nottingham Forest v Liverpool

Wednesday 15th January 2025

  • 19:30 GMT: Newcastle v Wolves
  • 19:30 GMT: Everton v Aston Villa
  • 19:30 GMT: Leicester v Crystal Palace
  • 20:00 GMT: Arsenal v Liverpool

Thursday 16th January 2025

  • 19:30 GMT: Ipswich v Brighton
  • 20:00 GMT: Manchester United v Southampton

Fantasy Gameweek 21 suggested picks

Lining up in a 3-4-3 formation, here are our suggested picks for Fantasy Gameweek 21 per position:

Goalkeeper

Andre Onana (Manchester United)

Fixture - Southampton (H)
Price - 5.4m
Ownership - 7.22%

Defenders

Lewis Hall (Newcastle)

Fixture - Wolves (H)
Price - 4.7m
Ownership - 22.55%

Harry Maguire (Manchester United)

Fixture - Southampton (H)
Price - 4.7m
Ownership - 0.97%

Daniel Munoz (Crystal Palace)

Fixture - Leicester (A)
Price - 4.7m
Ownership - 18.68%

Midfielders

Bruno Fernandes (Manchester United)

Fixture - Southampton (H)
Price - 8.4m
Ownership - 11.90%

Mohamed Salah (Liverpool)

Fixture - Nottingham Forest (A)
Price - 12.6m
Ownership - 70.88%

Cole Palmer (Chelsea)

Fixture - Bournemouth (H)
Price - 10.5m
Ownership - 72.56%

Jacob Murphy (Newcastle)

Fixture - Wolves (H)
Price - 5.5m
Ownership - 3.03%

Forwards

Alexander Isak (Newcastle)

Fixture - Wolves (H)
Price - 8.8m
Ownership - 55.11%

Jean-Philippe Mateta (Crystal Palace)

Fixture - Leicester (A)
Price - 7.2m
Ownership - 4.63%

Liam Delap (Ipswich)

Fixture - Brighton (H)
Price - 5.6m
Ownership - 4.07%

Fantasy Gameweek 21 Differentials

The following three suggested picks for Gameweek 21 are all currently owned by under 5% of EPL Fantasy Season Game managers:

Harry Maguire

Ownership - 0.97%

Manchester United recently triggered a one-year extension to Harry Maguire's contract, and this seems to have had a positive impact on his performances.

Maguire put in a stellar performance in the Red Devils' victory over Arsenal in the third round of the FA Cup, and Thursday could act as a great opportunity for him and Man Utd to record a clean sheet.

Facing a Southampton side who have scored less goals on the road than any other Premier League side this season (5), expect Ruben Amorim's defence to limit the Saints' output.

Jacob Murphy

Ownership - 3.03%

Jacob Murphy's 2024/25 Premier League campaign seems to have gone under the radar.

Newcastle's right winger has registered 10 goal contributions this term, averaging an involvement every 103 minutes.

While much of the praise goes to Alexander Isak and Anthony Gordon, Murphy's form suggests he could hurt Vitor Pereira's Wolves side on Wednesday night.

Jean-Philippe Mateta

Ownership - 4.63%

Jean-Philippe Mateta's 2023/24 campaign suggested the Frenchman could be an outside contender for this year's golden boot award, but Crystal Palace's slow start to the season was reflected by Mateta's output.

That said, Palace's number 14 was able to find the net in their last Premier League outing against Chelsea, scoring in the 82nd minute to rescue a point.

Facing a Leicester side who have conceded 44 goals this season, Mateta stands a good chance of adding to his five goals this campaign.

Fantasy Gameweek 21 Captain

Bruno Fernandes

With the usual captain pick, Mohamed Salah, facing a tough challenge in the form of Nottingham Forest, Bruno Fernandes takes the armband this week.

Fernandes was at the heart of the action in Manchester United's most recent league contest in a 2-2 draw away at Liverpool, registering an assist for Lisandro Martinez's opener.

Man Utd's captain could sense a great chance to add to his four league goals in the 2024/25 season, facing a Southampton side who haven't won away from home all season.

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