With the Russell Wilson era officially ending in Denver, the hopes of the Broncos will rest on the young, inexperienced shoulders of number one Draft pick Bo Nix this season.
But will the Arkansas-native lead his new charges to an opening weekend victory or will a rejuvenated Seahawks get their playoff bid off to a perfect start on home soil?
Here's everything you need to know ahead of Sunday's hugely-anticipated showdown.
Denver Broncos @ Seattle Seahawks is available to watch live via bet365's Live Streaming service, whilst subscribers of the NFL GamePass can also take in the action.
Major plays from the game, including touchdowns, will be shown live on NFL RedZone, which will be shown on Sky Sports Mix.
Denver Broncos @ Seattle Seahawks will take place at the near 70,000 capacity Lumen Field in Seattle, USA, with the game scheduled for an 21:05 (BST) start on Sunday 8th September 2024.
Denver Broncos and Seattle Seahawks were AFC West divisional rivals from 1977 until 2001, until the Seahawks moved to the NFC West.
In total, the two sides have locked horns on 57 occasions in competitive action, with Denver leading the series 35-22.
All but two of those meetings have taken place during the regular season with two encounters featuring in the post-season - the most notable being the 2014 NFL Championship Game, which the Seahawks dominated 43-8.
Denver Broncos wins | 35 |
Seattle Seahawks wins | 22 |
No injury concerns to report