Czechia take on South Africa in Atlanta as both sides look to pick up their first points of the 2026 World Cup.
South Africa were toppled by Mexico at the Azteca Stadium in the opening match of the tournament as goals from Julian Quinones and Raul Jimenez saw the co-hosts prevail.
If the taste of defeat left a sour taste in the mouths of the Bafana Bafana, their woes were compounded by the dismissals of Yaya Sithole and Themba Zwane as they were forced to play the final five minutes of the contest with nine men.
Both Sithole and Zwane must now serve a one-match suspension, forcing Hugo Broos to reshuffle his pack.
Czechia took the lead just before the hour mark against South Korea through Ladislav Krejčí, but they succumbed to defeat in their opening Group A fixture as goals from Hwang In-beom and Oh Hyeon-gyu saw the Taegeuk Warriors come from behind to secure all three points.
You sense defeat for either side will all but end their qualification hopes, even with the opportunity to progress as one of the eight best third-placed teams in the group stage.
Czechia manager Miroslav Koubek has made five changes from the side that was beaten by South Korea as Adam Hlozek and Vladimir Darida both enter the fray.
West Ham midfielder Tomas Soucek is dropped with Lukas Cerv forming a midfield partnership with Michal Sadilek.
Tomas Holes replaces Stepan Chaloupek in the central defensive three.
South Africa boss Broos has drafted in Thalente Mbatha to replace the suspended Sithole, while Oswin Appollis comes in for Zwane as the back five system is retained.
Burnley's Lyle Foster drops to the bench and Thapelo Maseko is selected to lead the line alongside Iqraam Rayners.
Kovar; Holes, Hranac, Krejci; Coufal, Cerv, Sojka, Sadilek; Hlozek, Darida; Schick.
Substitutes: Hornicek, Stanek, Chaloupek, Chory, Chytil, Doudera, Kuchta, Provod, Sochurek, Soucek, Sulc, Visinsky, Zeleny, Zima.
Williams; Mudau, Okon, Adams, Mbokazi, Modiba; Appollis, Mbatha, Mokoena; Maseko, Rayners.
Substitutes: Chaine, Goss, Cross, Foster, Kabini, Makgopa, Makhanya, Matuludi, Mofokeng, Moremi, Ndamane, Sebelebele, Sibisi.