England will look to back up their win at Trent Bridge on Saturday and secure a series victory against Ireland when the two sides meet in the third and final ODI at Bristol on Tuesday.
Ireland Opening Partnership Under 23.5 - 10/11
Ireland made a good start to their chase of 335 for victory on Saturday, taking full advantage of some wayward bowling from George Scrimshaw in particular.
The Derbyshire paceman, the first player from his county to feature for England for 21 years, suffered from some debut nerves as he delivered six no-balls and a wide in his first two overs.
Openers Paul Stirling and Andrew Balbirnie mercilessly made hay off of his free hits and took Ireland's score up to 46-0 before Scrimshaw redeemed himself by inducing Balbirnie to edge low to Ben Duckett at slip for the breakthrough.
The attacking nature of the Irish duo also often sees them push the run rate on in the early stages, but the risks involved have led to some underwhelming opening stands of late too.
The average runs for Ireland's first wicket in 2023 is 34.6, but eight of their 14 opening partnerships this year have fallen below the 23.5 run mark.
And given the average opening stand in ODIs at the County Ground dating back to 2017 is just 26, it may be worth taking the under here as the batters are also set to contend with cold, blustery conditions.
Craig Young Ireland Top Bowler - 9/2
In Nottingham, Ireland made one change from the side that beat Nepal in their last completed ODI, with seamer Craig Young replacing Gareth Delany.
Coming into the attack as a change-bowler, Young took two wickets in three balls - first removing Phil Salt, who clipped the ball straight to Stirling at extra cover for 28, and then trapping England captain Zak Crawley lbw for a duck.
The North Down paceman finished with figures of 2-38 off his seven overs and generated the highest ratio of dot balls in the Ireland attack.
The 33-year-old has picked up multiple wickets in each of his last three 50-over games for Ireland and struck at least one in his last 13 ODI appearances.
He should get some seam movement off a potentially quicker surface at Bristol in comparison to the wicket at Trent Bridge, which forced both teams to draw back their bowling length because of its flat nature.
Sam Hain England Top Batter - 6/1
Hain gained plenty of plaudits for his debut knock of 89 off 82 balls on Saturday, although there were some critical words from former England captain Eoin Morgan on commentary too.
Morgan may have held unrealistic expectations for the Warwickshire batter, who had scored a remarkable volume of runs in domestic 50-over cricket to earn his selection.
The 28-year-old's average of 58.6 in professional one-day cricket is the second-best in history and makes him the outstanding candidate to top score at Bristol.
Hain was outscored by Will Jacks at Trent Bridge, but should benefit from the experience of his debut and the likelihood that England's top four will have laid a good platform for him to express himself with the bat.
Tom Kohler-Cadmore could earn his first senior international cap after being added to the squad ahead of the second ODI.
The Somerset man could bolster England's batting line-up, with Luke Wood also pushing for a slot in the seam attack.
Craig Overton missed out at Trent Bridge with a back problem as Tom Hartley became one of four England debutants, while Jason Roy, who missed out on World Cup selection, has opted not to play against Ireland.
Ireland could hand a debut to New Zealand-born left-arm spinner Theo van Woerkom as they look to give others a chance in the wake of the defeat at Trent Bridge.
Captain Paul Stirling and Andy Balbirnie should remain at the top of the order, with Lorcan Tucker set to keep wicket again.
England's last two ODI scores at the County Ground have been winning totals of 359-4 and 369-9, while the hosts also beat Ireland with 127-3 in 2017, having bowled their opponents out for 126 in 33 overs.