Australia eased to an impressive seven-wicket victory over England in Thursday's first ODI at Trent Bridge and they will be aiming to take a 2-0 lead in the five-match series this weekend.
The second ODI between England and Australia will be broadcast live on Sky Sports Cricket.
England's second ODI against Australia starts at 11:00 on Saturday 21st September and it is taking place at Headingley in Leeds.
Australia recorded their 89th ODI victory against England at Trent Bridge on Thursday and the world champions have extended their winning streak in 50-over internationals to 13 matches.
The Aussies lost their first two league fixtures at last year's World Cup, but they have been unbeatable since then, defeating South Africa in the semi-finals and tournament hosts India in the final to lift the trophy for the sixth time.
Opener Travis Head was player of the match in the first T20I against Scotland earlier this month and he completed a hat-trick of awards in the first ODI in England, scoring a career-best 154 not out off 129 balls.
The lack of experience in the England squad is reflected by the fact that their leading ODI runscorer is Adil Rashid, who batted at number 11 in the opening game.
England wins | 63 |
Ties or no results | 5 |
Australia wins | 89 |
*H2H stats refer to all ODI meetings
Harry Brook is captaining England in this series as Jos Buttler is sidelined by a calf injury. Joe Root has been rested, but fast bowler Reece Topley should be available after missing the first ODI due to illness.
Australia hope to welcome back Mitchell Starc, Josh Hazlewood and Glenn Maxwell after sickness bouts, but paceman Ben Dwarshuis suffered a shoulder injury during his debut on Thursday and is set to miss out.