England's summer schedule concludes with a three-match T20I series and five ODIs against Australia and the Ashes rivals will be aiming to make a strong start in the first game in Southampton on Wednesday.
The first T20I between England and Australia will be shown live on Sky Sports Cricket and Sky Sports Main Event.
England's clash with Australia starts at 18:30 BST on Wednesday 11th September and it is being staged at the Rose Bowl in Southampton.
England and Australia have each won 11 of the 22 completed T20Is between the Ashes rivals, although the Aussies have lost six of their eight away games against England.
In May 2010, England defeated Australia by seven wickets in the T20 World Cup final in Bridgetown and both teams have enjoyed more recent success in the tournament.
Australia lifted the trophy in 2021, while England beat Pakistan in the 2022 final in Melbourne, but they lost June's T20 World Cup Group B clash with the Aussies in Barbados by 36 runs.
Jos Buttler's men still reached the semi-finals, where India thrashed them by 68 runs, while a shock defeat to Afghanistan ended Australia's hopes at the Super 8 stage.
England wins | 11 |
Ties/no results | 2 |
Australia wins | 11 |
*H2H stats refer to all T20I meetings
Read the latest tips, predictions and odds for England v Australia in their first T20I
Regular captain Buttler is sidelined with a calf injury, so his opening partner Phil Salt will lead the side.
Jacob Bethell and Jordan Cox will make their international debuts, while Jamie Overton will play in his first T20I and Saqib Mahmood returns to the fold after lengthy injury problems.
Fast bowler Nathan Ellis (hamstring) is injured, but Josh Hazlewood has joined the squad after sitting out the T20I series in Scotland.
Mitchell Starc and Pat Cummins are rested and fellow paceman Spencer Johnson has been ruled out of the whole tour with a side strain.