Sir Gino and Mystical Power are the favourites in our betting odds for the Fighting Fifth Hurdle at Newcastle after Constitution Hill was ruled out of the race.
(Odds will display when the market is available)
Nicky Henderson's stable star has been out of action since Boxing Day last year after missing the Cheltenham Festival through injury, and was all set to make his long-awaited comeback at Newcastle.
However, Constitution Hill was lame after a gallop at Newbury and could also miss the Christmas Hurdle at Leopardstown.
Henderson has confirmed that Sir Gino will go chasing this season and the unbeaten four-year-old is prominent at the top of the market ahead of the race.
Supreme Novices' Hurdle winner Mystical Power is likely to challenge at the start of what could be a stellar campaign, while Brentford Hope's odds have shortened after finishing second in the Elite Hurdle.