Barcelona are 16/1 to go unbeaten in La Liga following their 5-0 dismantling of Valencia at the Mestalla.
Hansi-Flick's men were emphatic during their latest league success; strikes from Fermin Lopez, Raphinha and Pedri added to a brace from superstar winger Lamine Yamal.
Barcelona have now won each of their four opening matches of the league season, seeing their price to win the title shorten into 4/7.
They are by far the highest-scoring team in Europe's top five leagues this season, already racking up 17 goals courtesy of two more five-goal victories over Elche and Rayo Vallecano.
Brazil international Raphinha has netted six goals and laid on an assist in just four La Liga appearances so far and has the advantage in the early stages to win the Golden Boot.
Hansi-Flick is currently presiding over an ultra-successful period as Blaugrana boss, overseeing back-to-back league triumphs, as well as lifting a Copa del Rey and two Supercopa de Espana titles.
Early indications are that things are bubbling up nicely at the Camp Nou again and Flick will be keen to make an impression in Europe. Barcelona favourites to win the UEFA Champions League at 5/1.
(Odds will display when market is available)
Odds displayed correct at time of publishing and subject to change or withdrawal at any time.