The traditional Thanksgiving Day triple-header starts with the Detroit Lions hosting the Buffalo Bills back at the venue where Sean McDermott's men got their season back on track a few days ago.
The Dallas Cowboys entertain the surprising New York Giants later on before the New England Patriots are the Minnesota Vikings' guests for the final course of the traditional Turkey Day football feast.
What: Buffalo Bills @ Detroit Lions
Where: Ford Field, Detroit, Michigan
When: 12.30 p.m. ET/9.30 a.m. PT Thursday, November 24th
How to watch: CBS, Streaming via Paramount+
Odds: BUF Bills -500, DET Lions +375
The Bills should be familiar with their surroundings at Ford Field after decamping to Detroit and beating the Cleveland Browns 31-23 when a snowstorm left their Highmark Stadium home blanketed last weekend.
They could be given a bit more trouble by the team that regularly occupy the home locker room after the Lions roared to a 31-18 road win over the New York Giants.
A few weeks ago, nobody would have given Dan Campbell's team a hope against the Super Bowl favourites, but the Lions have heated up just as the Bills caught their pre-snowstorm cold.
But Detroit's first three-game winning streak in five years has been achieved against a Green Bay Packers team that are now 4-7, a one-point victory over the 3-8 Chicago Bears and last week's success against an injury-hit Giants team that all the analytics suggested were fortunate to be where they were.
The Bills, who have won their last two Thanksgiving Day assignments, appear to have extracted themselves from an offensive rut and should make merry against a Lions defence that has given up the most yards per game and the most points per game, covering a -9.5 point Spread at -110.
What: New York Giants @ Dallas Cowboys
Where: AT&T Stadium, Arlington, Texas
When: 21:30, Thursday 24th November 2022
How to watch: Fox
Odds: NY Giants +325, DAL Cowboys -425
This late-afternoon matchup in Arlington marks the 45th consecutive Thanksgiving Day contest the Cowboys have hosted and this time it's against a division rival.
The two teams have identical 7-3 records and both appear to be jostling at the front of the queue for Odell Beckham Jr's signature as he prepares to make his return to an NFL roster.
But the Giants are so banged-up at the moment, it's hard to see how that can live with a Cowboys team that just handed the Minnesota Vikings the sixth-heaviest defeat in franchise history.
Big Blue saw five more players ruled out during their Week 11 loss to the Lions and have a lengthy list of game-time decisions to be made over right tackle Evan Neal, who has been out since Week 7 with a sprained MCL, safety Jason Pinnock (jaw), cornerback Fabian Moreau (oblique), center Jon Feliciano (neck), offensive tackle Tyre Phillips (neck) and wide receiver/punt returner Richie James (knee).
Neal was schooled by DeMarcus Lawrence, who recorded three sacks the last time these two NFC East rivals met in a game the Cowboys won 23-16 with Cooper Rush under center.
The Cowboys have won 10 of the past 11 games in this series and really should not let this opportunity to go clear at the top of the division pass them by covering the 9.0 point Spread at -110.
What: New England Patriots @ Minnesota Vikings
Where: U.S. Bank Stadium, Minneapolis
When: 01:20, Friday 25th November 2022
How to watch: NBC
Odds: Odds: NE Patriots +125, MIN Vikings -145
The Vikings look uneasy favourites for this one after taking a home shellacking from the Cowboys on Sunday while the Patriots were collecting their 14th win in a row over the New York Jets.
Many will scoff at the hosts' prospects because of the primetime slot and Minnesota QB Kirk Cousins' propensity to struggle under the national spotlight.
When he plays in the early window games, he almost never loses but he has come out on top in only three of his last eight primetime assignments, during which he has thrown ten interceptions.
The Patriots' highly-ranked defence didn't pick Zach Wilson off last week, but they did everything else to disrupt his flow and decision-making to the point where he appeared totally confused again.
It's easy to imagine how Bill Belichick, who admitted he got a headstart on preparing for this game during their bye, could craft something similar here, but the Vikings are 6-2 on Thanksgiving Day and have other playmakers beside their quarterback.
The Vikings are 8-2 because they tend to win close games and are worth supporting straight up here at -145.
Returns exclude Bet Credits wager. T&Cs, time limits and exclusions apply